Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging

S Vaezy; X Shi; R W Martin; E Chi; P I Nelson; M R Bailey; L A Crum

doi:10.1016/s0301-5629(00)00279-9

Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging

Ultrasound Med Biol. 2001 Jan;27(1):33-42. doi: 10.1016/s0301-5629(00)00279-9.

Authors

S Vaezy¹, X Shi, R W Martin, E Chi, P I Nelson, M R Bailey, L A Crum

Affiliation

¹ Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. adasi@u.washington.edu

PMID: 11295268
DOI: 10.1016/s0301-5629(00)00279-9

Abstract

High-intensity focused ultrasound (HIFU) and conventional B-mode ultrasound (US) imaging were synchronized to develop a system for real-time visualization of HIFU treatment. The system was tested in vivo in pig liver. The HIFU application resulted in the appearance of a hyperechoic spot at the focus that faded gradually after cessation of HIFU exposure. The duration of HIFU exposure needed for a hyperechoic spot to appear, was inversely related to the HIFU intensity. The threshold intensity required to produce a hyperechoic spot in liver in < 1 s was 970 W/cm(2), in situ. At this HIFU dose, no immediate cellular damage was observed, providing a potential for pretreatment targeting. The real-time visualization method was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment. Real-time US imaging may provide a useful tool for image-guided HIFU therapy.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Equipment Design
Liver / diagnostic imaging
Swine
Ultrasonic Therapy*
Ultrasonography / methods*

Grants and funding

1RO1HL64208/HL/NHLBI NIH HHS/United States