Abstract
Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology*
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Cryptococcosis / prevention & control*
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Cryptococcus neoformans / growth & development
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Female
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Immunization, Passive
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Levodopa / pharmacology
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Melanins / immunology*
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Mice
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Mice, Inbred C57BL
Substances
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Antibodies, Monoclonal
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Melanins
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Levodopa