Abstract
Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. Diagnostic problems and therapeutic alternatives are discussed considering the recent literature.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adult
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Diagnosis, Differential
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Heterozygote*
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Humans
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Male
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Necrosis
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Phenprocoumon / administration & dosage
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Phenprocoumon / adverse effects*
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Protein S Deficiency / diagnosis
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Protein S Deficiency / genetics*
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Skin / pathology*
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Thrombophlebitis / chemically induced*
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Thrombophlebitis / diagnosis