Effect of bioactive additive mammoleptin on development of transplanted tumors in mice

E P Zueva; E M Naumova; B G Valentinov; E N Amosova; T G Razina; S G Krylova; N V Shilova; V E Gol'dberg

Effect of bioactive additive mammoleptin on development of transplanted tumors in mice

Bull Exp Biol Med. 2000 Dec;130(12):1150-2.

Authors

E P Zueva¹, E M Naumova, B G Valentinov, E N Amosova, T G Razina, S G Krylova, N V Shilova, V E Gol'dberg

Affiliation

¹ Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.

PMID: 11276307

Abstract

Bioactive additive mammoleptin used for the treatment of fibrocystic breast disease did not stimulate the growth of primary tumors and metastases in mice with transplanted tumors. Mammoleptin in high doses inhibited the growth of Ehrlich adenocarcinoma and metastatic spreading of solid tumors.

MeSH terms

Animals
Biological Factors / pharmacology*
Female
Fibrocystic Breast Disease / drug therapy
Humans
Lung Neoplasms / drug therapy
Lung Neoplasms / pathology
Lung Neoplasms / secondary
Medicine, Chinese Traditional
Melanoma, Experimental / drug therapy
Melanoma, Experimental / pathology
Melanoma, Experimental / secondary
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Neoplasms, Experimental / drug therapy*
Neoplasms, Experimental / pathology
Neoplasms, Experimental / secondary
Plant Extracts / pharmacology*

Substances

Biological Factors
Plant Extracts