Isolation and characterization of cDNAs for the protein kinase HIPK2

Biochim Biophys Acta. 2001 Mar 19;1518(1-2):168-72. doi: 10.1016/s0167-4781(00)00308-0.

Abstract

HIPK2 (homeodomain-interacting protein kinase 2) is a CD95 binding partner in yeast. Its primary amino acid sequence is highly conserved between human and mouse. The highest HIPK2 mRNA expression is found in neuronal tissue. The HIPK2 gene is located on human chromosome 7q33-35 and the protein is mainly localized in the nucleus. HIPK2 has been described to play a role as a co-repressor for homeodomain transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Chromosomes, Human, Pair 7*
  • Codon, Initiator
  • DNA, Complementary
  • Female
  • Gene Expression
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Protein Serine-Threonine Kinases / genetics*
  • Protein Serine-Threonine Kinases / metabolism
  • RNA, Messenger
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Tumor Cells, Cultured
  • fas Receptor / metabolism*

Substances

  • Carrier Proteins
  • Codon, Initiator
  • DNA, Complementary
  • Nuclear Proteins
  • RNA, Messenger
  • fas Receptor
  • HIPK2 protein, human
  • Hipk2 protein, mouse
  • Protein Serine-Threonine Kinases

Associated data

  • GENBANK/AF208291
  • GENBANK/AF208292