Genetics of brugada, long QT, and arrhythmogenic right ventricular dysplasia syndromes

J Electrocardiol. 2000:33 Suppl:11-22. doi: 10.1054/jelc.2000.20361.

Abstract

This article outlines the up-to-date understanding of the molecular basis of primary ventricular arrhythmias. Two disorders have recently been well described at the molecular level, the long QT syndromes and Brugada syndrome, and this article reviews the current scientific knowledge of each disease. A third disorder, arrhythmogenic right ventricular dysplasia, which is on the cusp of understanding, will also be described.

Publication types

  • Review

MeSH terms

  • Arrhythmogenic Right Ventricular Dysplasia / diagnosis
  • Arrhythmogenic Right Ventricular Dysplasia / genetics*
  • Arrhythmogenic Right Ventricular Dysplasia / physiopathology
  • Bundle-Branch Block / diagnosis
  • Bundle-Branch Block / genetics*
  • Bundle-Branch Block / physiopathology
  • Death, Sudden, Cardiac / etiology
  • Electrocardiography
  • Humans
  • Ion Channels / genetics
  • Long QT Syndrome / diagnosis
  • Long QT Syndrome / genetics*
  • Long QT Syndrome / physiopathology
  • Mutation / genetics
  • Syndrome
  • Ventricular Fibrillation / diagnosis
  • Ventricular Fibrillation / genetics*
  • Ventricular Fibrillation / physiopathology

Substances

  • Ion Channels