Objective: To investigate the effect of hypertonic saline/dextran 70 on delayed resuscitation of burn shock.
Methods: Eighteen mongrel dogs with 35% TBSA, third-degree burn were used in this study. Lactated Ringer's (LR) or 7.5% NaCl+ 6% dextran 70 (HSD) was given for resuscitation 6 h postburn. The volumes and rates of fluid infusion were controlled basically on the urinary output of 1.0 ml.kg-1.h-1 and cardiac output (CO) of 70%-80% of preburn values. The volume load, +dp/dtmax, -dp/dtmax, CI,DO2 and VO2 were obtained to evaluate the effect of HSD resuscitation.
Results: The resuscitated volume of HSD was 30.56% less during first 24 h postburn and 59.50% less at 4 h after resuscitation than LR's. The +dp/dtmax, CI,DO2 and VO2 were increased significantly with HSD infusion at 2 h, 1 h and 0.5 h after resuscitation compared with LR's.
Conclusion: HSD could expand plasma volume significantly with small quantity. The cardiac contractility was enhanced and the oxygen delivery, oxygen consumption were increased in delayed resuscitation of burn shock.