Solution structure of (+)-discodermolide

Org Lett. 2001 Mar 8;3(5):695-8. doi: 10.1021/ol006967p.

Abstract

[structure: see text]. The solution structure of (+)-discodermolide (1) has been determined via 1- and 2-D NMR techniques in conjunction with Monte Carlo conformational analysis. Taken together, the results demonstrate that in solution (+)-discodermolide occupies a helical conformation remarkably similar to the solid state conformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkanes*
  • Animals
  • Carbamates*
  • Immunosuppressive Agents / chemistry*
  • Lactones / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Models, Molecular
  • Monte Carlo Method
  • Porifera / chemistry*
  • Pyrones
  • Solutions
  • Tubulin / chemistry

Substances

  • Alkanes
  • Carbamates
  • Immunosuppressive Agents
  • Lactones
  • Pyrones
  • Solutions
  • Tubulin
  • discodermolide