The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls

G D. Mellick; D D. Buchanan; N Hattori; A J. Brookes; Y Mizuno; D G. Le Couteur; P A. Silburn

doi:10.1016/s1353-8020(00)00018-3

The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls

Parkinsonism Relat Disord. 2001 Apr;7(2):89-91. doi: 10.1016/s1353-8020(00)00018-3.

Authors

G D. Mellick¹, D D. Buchanan, N Hattori, A J. Brookes, Y Mizuno, D G. Le Couteur, P A. Silburn

Affiliation

¹ Department of Medicine, University of Queensland, Princess Alexandra Hospital, Queensland, Woolloongabba, Australia

PMID: 11248588
DOI: 10.1016/s1353-8020(00)00018-3

Abstract

This study determined the frequencies of a G-to-A transition (S/N167) polymorphism in exon 4 of the parkin gene in Australian Parkinson's disease patients and control subjects. The genotype of each subject was determined using the polymerase chain reaction and restriction-fragment-length-polymorphism analysis. Overall, the A allele was significantly less common in the Parkinson's disease group (1.7%) compared with the control group (3.8%, OR=0.43, 95% CI=0.19-1.00, P<0.05), although the frequency in the young onset Parkinson's disease group (6.6%) was not significantly different to controls. The A allele is less common in Australian Caucasian subjects compared to Japanese Parkinson's disease patients and appears to be under-represented in older-onset Parkinson's disease.