Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten

Arch Pharm Res. 2001 Feb;24(1):51-4. doi: 10.1007/BF02976493.

Abstract

Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Citric Acid / chemistry
  • Citric Acid / isolation & purification
  • Citric Acid / pharmacology*
  • Citrus / chemistry*
  • Monoamine Oxidase / drug effects*
  • Monoamine Oxidase Inhibitors / chemistry
  • Monoamine Oxidase Inhibitors / isolation & purification
  • Monoamine Oxidase Inhibitors / pharmacology*

Substances

  • Monoamine Oxidase Inhibitors
  • Citric Acid
  • Monoamine Oxidase