Regulation of laminin and COUP-TF expression in extraembryonic endodermal cells

Mech Dev. 2001 Mar;101(1-2):213-5. doi: 10.1016/s0925-4773(00)00554-2.

Abstract

Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1, and that either COUP-TF is sufficient to induce expression of these laminin genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COUP Transcription Factor I
  • COUP Transcription Factors
  • DNA, Complementary / metabolism
  • DNA-Binding Proteins / biosynthesis*
  • Embryo, Mammalian / cytology
  • Endoderm / metabolism*
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Kinetics
  • Laminin / biosynthesis*
  • Mice
  • Receptors, Steroid*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stem Cells / metabolism
  • Time Factors
  • Tissue Distribution
  • Transcription Factors / biosynthesis*
  • Transfection
  • Up-Regulation*

Substances

  • COUP Transcription Factor I
  • COUP Transcription Factors
  • DNA, Complementary
  • DNA-Binding Proteins
  • Laminin
  • Nr2f1 protein, mouse
  • Receptors, Steroid
  • Transcription Factors