Comparison of cytology and nuclear matrix protein 22 for the detection and follow-up of bladder cancer

Urol Int. 2001;66(2):72-7. doi: 10.1159/000056574.

Abstract

Objectives: This study was designed to determine the clinical usefulness of the nuclear matrix

Methods: 84 patients suffering from bladder cancer or suspected bladder cancer, 25 patients with benign urological lesions and 60 healthy controls participated in a prospective study. Freshly voided spot urine samples were taken for cytological examination and determination of NMP 22 levels by enzyme-linked immunoassay.

Results: The sensitivity of the NMP 22 test according to the tumor grading was (results of cytology in brackets): G1 25.0% (20.0%); G2 68.2% (59.1%), and G3 100.0% (66.7); overall sensitivity was 62.5% (45.0%). The sensitivity for superficial bladder cancer was 46.7% (36.7%) and for invasive bladder cancer 90.0% (70.0%). The specificity was 65.9% (88.9%).

Conclusions: NMP 22 is a reliable tool for detecting invasive bladder cancer. Results for the frequently occurring low grade superficial bladder cancer are as poor as those obtained with cytology. In addition benign lesions such as urolithiasis or urinary tract infection lead to false-positive results. Therefore cystoscopy has to be performed when trying to detect and follow-up bladder cancer.

Publication types

  • Comparative Study

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Carcinoma, Transitional Cell / chemistry
  • Carcinoma, Transitional Cell / diagnosis*
  • Follow-Up Studies
  • Humans
  • Nuclear Proteins / analysis*
  • Prospective Studies
  • Sensitivity and Specificity
  • Urinary Bladder Neoplasms / chemistry
  • Urinary Bladder Neoplasms / diagnosis*

Substances

  • Biomarkers, Tumor
  • Nuclear Proteins
  • nuclear matrix protein 22