Primary intracerebral malignant melanoma with leptomeningeal spread, extradural extension and lung metastasis

Clin Neuropathol. 2001 Jan-Feb;20(1):43-5.

Abstract

A rare primary intracerebral solitary malignant melanoma with extracranial metastasis is reported. The patient was a 66-year-old man who was revealed to have a tumor in the right temporal lobe by MRI. The tumor was totally resected and the histopathological diagnosis was malignant melanoma. Despite postoperative treatment with chemo-radiotherapy, tumor recurred with multiple subarachnoid dissemination. Complete autopsy showed marked leptomeningeal dissemination of tumor in the cerebro-spinal compartment. In the outside of the central nervous system, a microscopic metastatic nodule was found in the right lung. Metastatic tumor in the spinal cord showed the extradural extension which might have led to hematogenous metastasis to the lung.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain Neoplasms / pathology*
  • Fatal Outcome
  • Humans
  • Lung Neoplasms / secondary*
  • Male
  • Melanoma / secondary*
  • Meningeal Neoplasms / secondary*