Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3'-3' inversion of polarity site

A Galeone; L Mayol; G Oliviero; D Rigano; M Varra

doi:10.1016/s0960-894x(00)00673-9

Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3'-3' inversion of polarity site

Bioorg Med Chem Lett. 2001 Feb 12;11(3):383-6. doi: 10.1016/s0960-894x(00)00673-9.

Authors

A Galeone¹, L Mayol, G Oliviero, D Rigano, M Varra

Affiliation

¹ Dip. di Chimica delle Sostanze Naturali, Univ. di Napoli Federico II, Italy.

PMID: 11212116
DOI: 10.1016/s0960-894x(00)00673-9

Abstract

The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2,2'-Dipyridyl / chemistry*
Base Pair Mismatch*
Ligands
Oligonucleotides / chemical synthesis*
Structure-Activity Relationship

Substances

Ligands
Oligonucleotides
2,2'-Dipyridyl