[Effectiveness of lymphotropic therapy in patients with tuberculosis in relations to genetic markers]

Probl Tuberk. 2000:(6):44-6.
[Article in Russian]

Abstract

To study whether a combination of the carriage of genetic blood markers: haptoglobin phenotypes and red blood cell glucose-6-phosphate dehydrogenase, 60 patients with destructive tuberculosis were given a new drug treatment regimen by using regional lymphotropic therapy with 10% isoniazid. The efficiency of the treatment and residual changes were found to be directly related to what a patient has as genetic background. Defining the types of combinations of genetic markers may predict the course of disease, the efficiency of treatment, and outcomes.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Antitubercular Agents / administration & dosage*
  • Erythrocytes / enzymology
  • Female
  • Genetic Markers
  • Glucosephosphate Dehydrogenase / blood
  • Glucosephosphate Dehydrogenase / genetics*
  • Haptoglobins / genetics*
  • Haptoglobins / metabolism
  • Humans
  • Injections, Intralymphatic
  • Male
  • Middle Aged
  • Phenotype
  • Treatment Outcome
  • Tuberculosis, Pulmonary / blood
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / genetics

Substances

  • Antitubercular Agents
  • Genetic Markers
  • Haptoglobins
  • Glucosephosphate Dehydrogenase