A case of alcohol withdrawal occurred in a patient affected by cancer of the oral cavity is reported. The patient underwent resection of the floor of the oral cavity, partial glossectomy mandibulectomy and neck dissection; reconstruction was done using microsurgical forearm radial flap. The patient didn't refer his alcohol dependence before operation and withdrawal symptoms with agitation, tachycardia, tachypnea, tremors and vomiting appeared during his postoperative recovery in intensive care where the patient was unable to take any alcohol. A therapeutic plan to use in patients operated for oral cancer with alcohol withdrawal (92% association of oral cancer with alcohol dependence) is reported.