Patients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells

N P Juffermans; P Speelman; A Verbon; J Veenstra; C Jie; S J van Deventer; T van Der Poll

doi:10.1086/318701

Patients with active tuberculosis have increased expression of HIV coreceptors CXCR4 and CCR5 on CD4(+) T cells

Clin Infect Dis. 2001 Feb 15;32(4):650-2. doi: 10.1086/318701. Epub 2001 Feb 7.

Authors

N P Juffermans¹, P Speelman, A Verbon, J Veenstra, C Jie, S J van Deventer, T van Der Poll

Affiliation

¹ Laboratory of Experimental Internal Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 11181132
DOI: 10.1086/318701

Abstract

Expression of human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5 was found to be elevated on CD4(+) T cells (1) in blood samples obtained from patients with tuberculosis and (2) in blood samples obtained from healthy subjects and stimulated with mycobacterial lipoarabinomannan in vitro. These data suggest that the increase in HIV viremia that occurs in association with tuberculosis may result from up-regulation of CXCR4 and CCR5 on CD4(+) T cells, thereby causing acceleration of HIV infection.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
CD4-Positive T-Lymphocytes / metabolism*
HIV Seronegativity / immunology
HIV Seropositivity / complications*
HIV Seropositivity / immunology
Humans
Lipopolysaccharides / pharmacology
Lymphocyte Activation
Mycobacterium tuberculosis / immunology*
Receptors, CCR5 / metabolism*
Receptors, CXCR4 / metabolism*
Tuberculosis, Pulmonary / immunology*
Tuberculosis, Pulmonary / microbiology

Substances

Lipopolysaccharides
Receptors, CCR5
Receptors, CXCR4
lipoarabinomannan