Abstract
In a bioassay-guided search for neuroprotective compounds from medicinal plants, a MeOH extract of whole plants of Hedoytis diffusa yielded five flavonol glycosides, kaempferol 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (1), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-galactopyranoside (2), quercetin 3-O-[2-O-(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-D-glucopyranoside (3), kaempferol 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (4), and quercetin 3-O-(2-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside (5), and four O-acylated iridoid glycosides (6-9). Compounds 1 and 2 are previously unreported natural products, and all nine compounds exhibited significant neuroprotective activity in primary cultures of rat cortical cells damaged by L-glutamate.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Survival / drug effects
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Cells, Cultured
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Cerebral Cortex / cytology
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Kaempferols*
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Magnetic Resonance Spectroscopy
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Neurons / drug effects
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology
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Plants, Medicinal / chemistry*
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Quercetin / analogs & derivatives
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Rats
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Rats, Sprague-Dawley
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Rubiaceae / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Ultraviolet
Substances
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Flavonoids
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Glycosides
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Kaempferols
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Neuroprotective Agents
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kaempferol
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Quercetin