The aim of this prospective randomized controlled clinical trial was to evaluate a set of clinical items and prosthetic aftercare of edentulous patients with a mandibular overdenture retained by 2 IMZ implants or 2 Brånemark implants during a 5-years' period. Patients were allocated to the IMZ group (n = 29) or the Brånemark group (n = 32) by a computerized balancing method. In the IMZ group 4 implants were lost during the 5-years' follow-up (survival rate: 93%). In the Brånemark group 9 implants were lost (survival rate: 86%). All patients were re-operated successfully. Multiple prosthetic revisions were necessary in both groups, especially the precision attachment system in the overdenture was subject to frequent fracture or loosening. From this study can be concluded that there is no difference in clinical state, radiographical state, survival rate and clinical implant performance between the IMZ implant system and the Brånemark implant system supporting an overdenture on 2 implants after 5 years of follow-up.