Macroscopic extranodal invasion is a risk factor for tumor recurrence in papillary thyroid cancer

Cancer Lett. 2001 Mar 10;164(1):85-9. doi: 10.1016/s0304-3835(00)00698-4.

Abstract

Papillary thyroid cancer patients, upon whom curative operation was performed, were investigated to clarify whether or not macroscopic extranodal invasion is a risk factor for recurrence. They were divided into three groups: group A, patients whose primary tumor showed extrathyroidal invasion (n=31); group B, those whose metastatic lymph nodes showed extranodal invasion (n=6); group C, those who showed both extrathyroidal and extranodal invasion (n=9). Recurrence was significantly higher in groups B and C than in group A (P<0.05). It was concluded that macroscopic extranodal invasion to the adjacent structures was a risk factor for recurrence in patients with papillary thyroid cancer.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Papillary / pathology*
  • Carcinoma, Papillary / surgery
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Recurrence
  • Risk Factors
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / surgery