Evaluation of pleomorphic xanthoastrocytoma by use of positron emission tomography with

AJNR Am J Neuroradiol. 2001 Feb;22(2):311-3.

Abstract

We present a case of pleomorphic xanthoastrocytoma (PXA) in a patient with temporal lobe seizures. Imaging sequences included MR, and results of positron emission tomography (PET) with [18F]-fluorodeoxyglucose (FDG) and [11C]-methionine (Met) tracers revealed a hypermetabolic region equivalent or nearly equivalent to normal cerebral cortex, suggesting that the tumor might have malignant potential. Histopathologic findings indicated low-grade glioma. The mechanism for glucose hypermetabolic activity of PXA is not clear; however, the positive findings obtained from FDG-PET may not always indicate the degree of malignancy associated with PXA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Astrocytoma / diagnosis
  • Astrocytoma / diagnostic imaging*
  • Astrocytoma / pathology
  • Brain Neoplasms / diagnosis
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Carbon Radioisotopes
  • Female
  • Fluorodeoxyglucose F18*
  • Humans
  • Magnetic Resonance Imaging
  • Methionine*
  • Radiography
  • Radiopharmaceuticals*
  • Tomography, Emission-Computed*

Substances

  • Carbon Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Methionine