The surgical methods and results of disconnective surgery for pediatric epilepsy were retrospectively analyzed. The techniques of neuronal disconnection included multiple subpial resection (MST), corpus callosotomy. and functional hemispherectomy by disconnection. Of 158 total pediatric operations, disconnective techniques were employed in more than 60% of the cases. MST was applied when the epileptic focus was located in unresectable cortices such as speech or motor areas. MST was also instrumental when the epileptogenic zone was extensive and was widely disseminated, as is often observed in cases of neocortical epilepsy. Of 25 patients who underwent MST, surgical outcomes after > 1 year follow-up showed Engel Class I or II in 10 cases, Class III in 12, and Class IV in 3. No mortality or morbidity was encountered during surgery or postoperatively. Corpus callosotomy was applied to cases of disabling generalized seizures and showed a marked effect in alleviating potentially injurious drop attacks. Of 34 patients with drop attacks, 29 became free from this type of seizure, 4 had infrequent attacks, and only 1 showed no beneficial effect. Postoperative improvement of cognition and speech was recognized in 77% of the cases. We developed a new method of functional hemispherectomy by fiber disconnection and applied this less invasive technique to 23 cases of hemispheric lesions. Of the 17 cases with > 1 year follow-up, 13 were in Class I or II, and 3 in Class III, and 2 in Class IV. Development partially normalized in infants with good seizure outcomes.