Nitroimidazoles and hypoxia imaging: synthesis of three technetium-99m complexes bearing a nitroimidazole group: biological results

Bioorg Med Chem Lett. 2001 Jan 8;11(1):71-4. doi: 10.1016/s0960-894x(00)00593-x.

Abstract

Several Tc-99m complexes were synthesized, substituted with a nitroimidazole group, in order to visualize hypoxic tissues. The complexes were tested on rats (isolated hearts) and showed no significant uptake under hypoxic conditions.

MeSH terms

  • Animals
  • Heart / diagnostic imaging
  • Heart / physiopathology
  • Hypoxia / diagnostic imaging*
  • In Vitro Techniques
  • Ligands
  • Molecular Structure
  • Nitroimidazoles / chemical synthesis*
  • Nitroimidazoles / chemistry
  • Nitroimidazoles / metabolism
  • Perfusion
  • Radionuclide Imaging
  • Rats
  • Technetium / metabolism
  • Technetium Compounds / chemical synthesis*
  • Technetium Compounds / chemistry
  • Technetium Compounds / metabolism

Substances

  • Ligands
  • Nitroimidazoles
  • Technetium Compounds
  • Technetium