Dynamics of autocatalytic replicator networks based on higher-order ligation reactions

Bull Math Biol. 2000 Nov;62(6):1061-86. doi: 10.1006/bulm.2000.0194.

Abstract

A class of autocatalytic reaction networks based on template-dependent ligation and higher-order catalysis is analysed. Apart from an irreversible ligation reaction we consider only reversible aggregation steps that provide a realistic description of molecular recognition. The overall dynamics can be understood by means of replicator equations with highly non-linear interaction functions. The dynamics depends crucially on the total concentration c0 of replicating material. For small c0, in the hyperbolic growth regime, we recover the familiar dynamics of second-order replicator equations with its wealth of complex dynamics ranging from multi-stability to periodic and strange attractors as well as to heteroclinic orbits. For large c0, in the parabolic growth regime, product inhibition becomes dominating and we observe a single globally stable equilibrium tantamount to permanent coexistence. In an intermediate parameter range we sometimes observe a behavior that is reminiscent of 'survival of the fittest'. Independently replicating species (Schlögl's model) and the hypercycle are discussed in detail.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Computer Simulation
  • Kinetics
  • Models, Biological*
  • Models, Chemical*
  • RNA / chemistry
  • Templates, Genetic

Substances

  • RNA