Non-FcR-binding, humanized anti-CD3 antibody Hu291 induces apoptosis of human T cells more effectively than OKT3 and is immunosuppressive in vivo

Transplant Proc. 2000 Nov;32(7):1545-6. doi: 10.1016/s0041-1345(00)01343-9.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology*
  • Apoptosis / drug effects
  • Apoptosis / immunology*
  • Graft vs Host Disease / prevention & control
  • Humans
  • Immunosuppressive Agents / pharmacology*
  • Lymphocyte Transfusion*
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Muromonab-CD3 / pharmacology*
  • Receptor-CD3 Complex, Antigen, T-Cell / immunology
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / immunology
  • Transplantation, Heterologous / immunology*

Substances

  • Antibodies, Monoclonal
  • Immunosuppressive Agents
  • Muromonab-CD3
  • Receptor-CD3 Complex, Antigen, T-Cell