Why Helicobacter pylori has Lewis antigens

B J Appelmelk; M A Monteiro; S L Martin; A P Moran; C M Vandenbroucke-Grauls

doi:10.1016/s0966-842x(00)01875-8

Why Helicobacter pylori has Lewis antigens

Trends Microbiol. 2000 Dec;8(12):565-70. doi: 10.1016/s0966-842x(00)01875-8.

Authors

B J Appelmelk¹, M A Monteiro, S L Martin, A P Moran, C M Vandenbroucke-Grauls

Affiliation

¹ Dept of Medical Microbiology, Vrije Universiteit, van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. bj.appelmelk.mm@med.vu.nl

PMID: 11115753
DOI: 10.1016/s0966-842x(00)01875-8

Abstract

In mimicry with human gastric epithelial cells, the lipopolysaccharide of Helicobacter pylori expresses Lewis blood group antigens. Recent data suggest that molecular mimicry does not promote immune evasion, nor does it lead to induction of autoantibodies, but that H. pylori Lewis X mediates adhesion to gastric epithelial cells and is essential for colonization.

Publication types

Review

MeSH terms

Bacterial Adhesion / physiology
Carbohydrate Sequence
Helicobacter Infections / microbiology*
Helicobacter pylori / immunology
Helicobacter pylori / pathogenicity*
Helicobacter pylori / physiology
Humans
Lewis Blood Group Antigens / chemistry
Lewis Blood Group Antigens / immunology
Lewis Blood Group Antigens / physiology*
Molecular Mimicry
Molecular Sequence Data
O Antigens / chemistry
O Antigens / immunology
O Antigens / physiology*
Virulence

Substances

Lewis Blood Group Antigens
O Antigens