The aim of our study was to comparison of a thickness of endometrium and blood flow parameters measured by transvaginal ultrasonography with color and "power" angio Doppler. We examined 81 women in perimenopausal period. Blood flow characteristics and histopathological changes were evaluated. There were no endometrial changes in 34 women. We detected 22 perimenopausal women and 12 postmenopausal with endometrial hyperplasia. In 13 cases we find endometrial carcinoma, 10 in postmenopausal women. Transvaginal ultrasonography with color Doppler can be using to diagnose pathology of endometrium providing that all suspicious images will be verified by other more invasive method.