Synthesis and in vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives

H Lee; J Lee; S S Hong; S I Yang; S H Jung; Y Jahng; J Cho

doi:10.1007/BF02976570

Synthesis and in vitro cytotoxicity of 2-alkylaminosubstituted quinoline derivatives

Arch Pharm Res. 2000 Oct;23(5):450-4. doi: 10.1007/BF02976570.

Authors

H Lee¹, J Lee, S S Hong, S I Yang, S H Jung, Y Jahng, J Cho

Affiliation

¹ College of Pharmacy, Chungbuk National University, Cheongju, Korea. medchem@trut.chungbuk.ac.kr

PMID: 11059821
DOI: 10.1007/BF02976570

Abstract

Eight 2-alkylaminosubstituted 5,8-dimethoxy-4-methylquinolines and nine 2-alkylaminosubstituted or 2,6-disubstituted 4-methylquinoline-5,8-diones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, HCT15 and SF295).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Humans
Quinolines / chemical synthesis*
Quinolines / pharmacology
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Quinolines