Crystallization and preliminary X-ray analysis of CTLA-4 (CD152) membrane-external domain

Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1468-9. doi: 10.1107/s0907444900010738.

Abstract

CTLA-4 (CD152) is involved in T-lymphocyte co-stimulatory pathways modulating both humoral and cellular immune response. The membrane-external domain has been prepared and crystallized. The unit-cell parameters are a = b = 43, c = 143 A with the symmetry of space group P3(1)21 or its enantiomer and the crystals diffract to 2. 7 A resolution at synchrotron beamlines.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abatacept
  • Antigens, CD
  • Antigens, Differentiation / chemistry*
  • CTLA-4 Antigen
  • Crystallization
  • Crystallography, X-Ray
  • Immunoconjugates*
  • Membrane Proteins / chemistry*
  • Protein Conformation

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • CTLA-4 Antigen
  • Immunoconjugates
  • Membrane Proteins
  • Abatacept