Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry

J Med Chem. 2000 Oct 19;43(21):3827-31. doi: 10.1021/jm000316h.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CHO Cells
  • COS Cells
  • Cricetinae
  • Glucosides / chemical synthesis*
  • Glucosides / chemistry
  • Glucosides / metabolism
  • Glucosides / pharmacology
  • Humans
  • Membrane Proteins
  • Molecular Mimicry
  • Neurokinin-1 Receptor Antagonists*
  • Receptors, Neurokinin-1 / metabolism
  • Receptors, Somatostatin / agonists
  • Receptors, Somatostatin / antagonists & inhibitors*
  • Receptors, Somatostatin / metabolism
  • Somatostatin / agonists
  • Somatostatin / chemistry*
  • Substance P / antagonists & inhibitors*

Substances

  • Glucosides
  • Membrane Proteins
  • Neurokinin-1 Receptor Antagonists
  • Receptors, Neurokinin-1
  • Receptors, Somatostatin
  • somatostatin receptor subtype-4
  • Substance P
  • Somatostatin