Familial ovarian malignancy

Hosp Med. 2000 Aug;61(8):528-31. doi: 10.12968/hosp.2000.61.8.1393.

Abstract

Familial ovarian cancer is a subset of ovarian cancer where there appears to be a definable genetic link in families. It accounts for less than 5% of cases of ovarian cancer seen at present. The main genes responsible, BRCA1 and BRCA2, are discussed. Screening and the prophylactic measures for women identified having a genetic trait are discussed.

Publication types

  • Review

MeSH terms

  • Adult
  • Aged
  • BRCA1 Protein / genetics
  • BRCA2 Protein
  • Contraceptives, Oral / therapeutic use
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Mass Screening
  • Middle Aged
  • Mutation
  • Neoplasm Proteins / genetics*
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / prevention & control
  • Ovariectomy
  • Prevalence
  • Risk
  • Transcription Factors / genetics

Substances

  • BRCA1 Protein
  • BRCA2 Protein
  • Contraceptives, Oral
  • Neoplasm Proteins
  • Transcription Factors