Abstract
We studied the persistence of porcine reproductive and respiratory syndrome virus (PRRSV) in individual experimentally infected pigs, during a period of up to 150 days postinfection (dpi). The results of this study suggest that the persistence of PRRSV involves continuous viral replication but that it is not a true steady-state persistent infection. The virus eventually clears the body and seems to do it in most of the animals by 150 dpi or shortly thereafter. High genetic stability was seen for several regions of the persistent PRRSV's genome, although some consistent mutations in the genes of envelope glycoproteins and M protein were also observed.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Amino Acid Substitution
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Animals
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Chronic Disease
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Gene Expression
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Molecular Sequence Data
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Porcine Reproductive and Respiratory Syndrome / virology*
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Porcine respiratory and reproductive syndrome virus / genetics
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Porcine respiratory and reproductive syndrome virus / isolation & purification
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Porcine respiratory and reproductive syndrome virus / physiology*
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Swine
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Viral Proteins / genetics
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Viral Proteins / metabolism
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Virus Replication
Associated data
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GENBANK/AF299404
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GENBANK/AF299405
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GENBANK/AF299406
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GENBANK/AF299407
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GENBANK/AF299408
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GENBANK/AF299409
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GENBANK/AF299410
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GENBANK/AF299411
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GENBANK/AF299412
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GENBANK/AF299413
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GENBANK/AF299414
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GENBANK/AF299415
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GENBANK/AF299416
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GENBANK/AF299417