Abstract
Some new pyrazolo[3,4-b]pyrazines and related heterocycles were synthesized and evaluated for their antifungal and antiparasitic activities. The key intermediate, 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carbonitrile (3) was obtained in a one-pot synthesis via the reaction of 5-amino-3-methyl-4-nitroso-1-phenylpyrazole 2 with malononitrile.
MeSH terms
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Animals
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / pharmacology
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Fungi / drug effects
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Leishmania / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Parasites / drug effects*
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Pyrazines / chemical synthesis*
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Pyrazines / pharmacology
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology
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Spectrophotometry, Infrared
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Trichomonas vaginalis / drug effects
Substances
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Antifungal Agents
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Pyrazines
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Pyrazoles