Hemolytic polar steroidal constituents of the starfish Aphelasterias japonica

J Nat Prod. 2000 Aug;63(8):1178-81. doi: 10.1021/np000030f.

Abstract

A reinvestigation of the polar steroid fraction from the starfish Aphelasterias japonica, collected near the Russian shore of the Sea of Japan, has afforded two new compounds, the disulfated quinovoside aphelasteroside C (1) and the monosulfated polyhydroxysteroid aphelaketotriol (2). Compounds 1 and 2 contain a unique 23-oxo-24-hydroxylated side chain that is unprecedented in marine steroids. The known compounds cheliferoside L1 (3), 3-O-sulfoasterone (4), forbeside E3 (5), and 3-O-sulfothornasterol A (6) were also isolated from this source. Compounds 1-3, 5, and 6 showed hemolytic activity to mouse erythrocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Assay
  • Chromatography, Gel
  • Chromatography, High Pressure Liquid
  • Chromatography, Ion Exchange
  • Chromatography, Thin Layer
  • Erythrocytes / chemistry
  • Magnetic Resonance Spectroscopy
  • Mice
  • Optical Rotation
  • Russia
  • Sodium / analysis
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Atomic
  • Spectrophotometry, Infrared
  • Starfish / chemistry*
  • Steroids / chemistry
  • Steroids / isolation & purification*
  • Steroids / pharmacology

Substances

  • Steroids
  • aphelaketotriol
  • aphelasteroside C
  • Sodium