Prevalence of CagA and VacA antibodies in children with Helicobacter pylori-associated peptic ulcer compared to prevalence in pediatric patients with active or nonactive chronic gastritis

Clin Diagn Lab Immunol. 2000 Sep;7(5):842-4. doi: 10.1128/CDLI.7.5.842-844.2000.

Abstract

VacA and CagA serological responses were detected in pediatric patients: 44 and 56%, respectively, in peptic ulcer (PU) patients, 33.3 and 44.4% in active chronic gastritis (ACG) patients, and 23.2 and 39.2% in non-ACG patients. Higher seroprevalence to CagA+VacA and to CagA+VacA+35-kDa antigen was found among PU patients. However, a low level of sensitivity and specificity was found for indirect detection of PU patients.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial / immunology*
  • Bacterial Proteins / immunology*
  • Blotting, Western / methods
  • Child
  • Child, Preschool
  • Chronic Disease
  • Female
  • Gastritis / blood
  • Gastritis / epidemiology
  • Gastritis / immunology*
  • Helicobacter Infections / blood
  • Helicobacter Infections / epidemiology
  • Helicobacter Infections / immunology*
  • Helicobacter pylori / immunology
  • Humans
  • Male
  • Peptic Ulcer / blood
  • Peptic Ulcer / epidemiology
  • Peptic Ulcer / immunology*
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Seroepidemiologic Studies
  • Spain / epidemiology

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Bacterial Proteins
  • VacA protein, Helicobacter pylori
  • cagA protein, Helicobacter pylori