Strain-dependent association between lateralization and lipopolysaccharide- induced IL-1beta and IL-6 production in mice

Neuroimmunomodulation. 2000;8(2):78-82. doi: 10.1159/000026456.

Abstract

Objective: The brain modulates the immune system in an asymmetrical way, as shown by the association between paw preference and immune response in the mouse. We predicted that the production of cytokines, which are one of the molecular pathways for brain-immune interactions, should be linked to lateralization in a strain-dependent manner.

Methods: We therefore measured plasma levels of interleukin (IL)-1beta and IL-6 after an intraperitoneal injection of lipopolysaccharide (LPS) in two strains of mice (C3H and BALB/c) that were selected for their different profiles of cytokine production.

Results: Plasma levels of IL-1beta and IL-6 increased after LPS injection in both strains and this increase was dependent on paw preference in BALB/c but not in C3H mice. Increased levels of IL-1beta were observed in left-pawed and ambidextrous but not in right-pawed mice. For IL-6, the LPS-induced increase was higher in ambidextrous than in left- and right-pawed animals.

Conclusion: Cytokines may represent one of the factors responsible for interindividual differences in brain-immune interactions.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Brain / immunology
  • Female
  • Forelimb
  • Functional Laterality / physiology*
  • Injections, Intraperitoneal
  • Interleukin-1 / blood*
  • Interleukin-6 / blood*
  • Lipopolysaccharides / pharmacology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Neuroimmunomodulation / drug effects*
  • Species Specificity

Substances

  • Interleukin-1
  • Interleukin-6
  • Lipopolysaccharides