Molecular biology of the androgen receptor

Abstract

The androgen receptor is a member of a superfamily of nuclear transcription factors that mediate the action of steroid hormones. When activated by ligand binding, these transcription factors bind to specific DNA sequences on target genes and regulate the transcriptional activity of those genes. Various genes have been identified that are regulated by androgens, including prostate-specific antigen (PSA). PSA contains an upstream glucocorticoid response element/androgen response element, so it is believed that androgens directly regulate its transcription rate. Despite this, posttranscriptional regulation through stability of the messenger RNA product is believed to be a major mechanism of androgens' effects.