Concentrations of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in human bone cell conditioned medium do not change with age

Mech Ageing Dev. 2000 Aug 15;117(1-3):109-14. doi: 10.1016/s0047-6374(00)00132-9.

Abstract

We examined the effects of age on the secretion of insulin-like growth factor (IGF)-I, -II, and IGF binding protein-4, and -5 in long-term bone cell cultures from 71 female donors, aged 28-79 years. Our results suggest that under basal conditions, the intrinsic capacity of human bone cells to produce these IGF components is largely preserved with age.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aging / metabolism*
  • Cells, Cultured
  • Culture Media, Conditioned
  • Female
  • Humans
  • Ilium / cytology
  • Ilium / metabolism
  • Insulin-Like Growth Factor Binding Protein 4 / metabolism*
  • Insulin-Like Growth Factor Binding Protein 5 / metabolism*
  • Insulin-Like Growth Factor I / metabolism*
  • Insulin-Like Growth Factor II / metabolism*
  • Middle Aged

Substances

  • Culture Media, Conditioned
  • Insulin-Like Growth Factor Binding Protein 4
  • Insulin-Like Growth Factor Binding Protein 5
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II