Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Mov Disord. 2000 Jul;15(4):714-9. doi: 10.1002/1531-8257(200007)15:4<714::aid-mds1018>3.0.co;2-3.

Abstract

We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE epsilon2/epsilon3 genotype than in cases with the epsilon3/epsilon3 genotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Apolipoproteins E / genetics*
  • Arylamine N-Acetyltransferase / blood
  • Arylamine N-Acetyltransferase / genetics*
  • Case-Control Studies
  • Cytochrome P-450 CYP2D6 / blood
  • Cytochrome P-450 CYP2D6 / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / diagnosis
  • Parkinson Disease / enzymology
  • Parkinson Disease / genetics*
  • Polymorphism, Genetic / genetics*

Substances

  • Apolipoproteins E
  • Cytochrome P-450 CYP2D6
  • Arylamine N-Acetyltransferase
  • NAT2 protein, human