Abstract
To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8. HDAC8 shows a high degree of sequence similarity to HDAC1 and HDAC2 and thus belongs to the class I of HDACs. HDAC8 is expressed in a variety of tissues. Human cells overexpressing HDAC8 localize the protein in sub-nuclear compartments whereas HDAC1 shows an even nuclear distribution. In addition, the HDAC8 gene is localized on the X chromosome at position q13, which is close to the XIST gene and chromosomal breakpoints associated with preleukemia.
MeSH terms
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Amino Acid Sequence
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Cell Line
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Cell Nucleus / chemistry
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Chromosome Breakage / genetics
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Cloning, Molecular
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Expressed Sequence Tags
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Gene Expression Profiling
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Histone Deacetylases / chemistry
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Histone Deacetylases / classification
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Histone Deacetylases / genetics*
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Histone Deacetylases / metabolism*
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Histones / metabolism
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Humans
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In Situ Hybridization, Fluorescence
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Leukemia / genetics
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Molecular Sequence Data
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Phylogeny
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Physical Chromosome Mapping
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Precancerous Conditions / genetics
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RNA, Long Noncoding
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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RNA, Untranslated*
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Repressor Proteins / chemistry
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Repressor Proteins / classification
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Repressor Proteins / genetics*
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Repressor Proteins / metabolism*
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Sequence Alignment
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Sequence Homology, Amino Acid
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Transcription Factors / genetics
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Transfection
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X Chromosome / genetics
Substances
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Histones
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RNA, Long Noncoding
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RNA, Messenger
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RNA, Untranslated
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Repressor Proteins
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Transcription Factors
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XIST non-coding RNA
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HDAC8 protein, human
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Histone Deacetylases
Associated data
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GENBANK/AJ239320
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GENBANK/AL133500