Objective: To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma.
Methods: Thirty-four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity.
Results: Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity.
Conclusion: Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.