[Telomerase activity in human primary endometrial carcinoma]

Zhonghua Zhong Liu Za Zhi. 1998 Nov;20(6):428-30.
[Article in Chinese]

Abstract

Objective: To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma.

Methods: Thirty-four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity.

Results: Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity.

Conclusion: Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.

Publication types

  • English Abstract

MeSH terms

  • Adenocarcinoma / enzymology*
  • Biomarkers, Tumor
  • Endometrial Neoplasms / enzymology*
  • Female
  • Humans
  • Telomerase / metabolism*

Substances

  • Biomarkers, Tumor
  • Telomerase