Difluoroketones as inhibitors of matrix metalloprotease-13

Bioorg Med Chem Lett. 2000 Jul 17;10(14):1581-4. doi: 10.1016/s0960-894x(00)00287-0.

Abstract

Substrate-like difluoroketones have been prepared as potential inhibitors of MMP-13. Weak inhibition was seen with the key target 2. This and the more potent activity of intermediate 7b illustrates that hydrated ketones can be used to inhibit MMP-13 and perhaps other members of this class of enzymes.

MeSH terms

  • Drug Design
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Ketones / pharmacology
  • Kinetics
  • Matrix Metalloproteinase 13
  • Matrix Metalloproteinase Inhibitors*
  • Molecular Structure
  • Protease Inhibitors / chemical synthesis*
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / pharmacology
  • Structure-Activity Relationship

Substances

  • Ketones
  • Matrix Metalloproteinase Inhibitors
  • Protease Inhibitors
  • Matrix Metalloproteinase 13