Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus alpha(v) integrins

J Virol. 2000 Aug;74(16):7691-3. doi: 10.1128/jvi.74.16.7691-7693.2000.

Abstract

Selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, alpha(v) integrins, and sialic acid on target cells. Initial interactions of subgenus D adenoviruses with target cells have until now been poorly characterized. Here, we demonstrate that adenovirus type 8 (Ad8), Ad19a, and Ad37 use sialic acid as a functional cellular receptor, whereas the Ad9 and Ad19 prototypes do not.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviruses, Human / classification
  • Adenoviruses, Human / genetics
  • Adenoviruses, Human / metabolism*
  • Amino Acid Motifs
  • Amino Acid Sequence
  • Antigens, CD / metabolism*
  • Capsid / chemistry
  • Capsid / genetics
  • Capsid Proteins*
  • Enterovirus B, Human / metabolism
  • Humans
  • Integrin alphaV
  • Molecular Sequence Data
  • N-Acetylneuraminic Acid / metabolism*
  • Receptors, Virus / metabolism*
  • Tumor Cells, Cultured

Substances

  • Antigens, CD
  • Capsid Proteins
  • Integrin alphaV
  • Receptors, Virus
  • penton protein, adenovirus
  • N-Acetylneuraminic Acid

Associated data

  • GENBANK/AF217407
  • GENBANK/AF217408
  • GENBANK/AF217409
  • GENBANK/AF217410