Palladium-Catalyzed cross-Benzannulation of Aminoenynes with Diynes. Highly Regioselective Synthesis of Polysubstituted Anilines

S Saito; N Uchiyama; V Gevorgyan V; Y Yamamoto

doi:10.1021/jo000171m

Palladium-Catalyzed cross-Benzannulation of Aminoenynes with Diynes. Highly Regioselective Synthesis of Polysubstituted Anilines

J Org Chem. 2000 Jul 14;65(14):4338-4341. doi: 10.1021/jo000171m.

Authors

S Saito¹, N Uchiyama, V Gevorgyan V, Y Yamamoto

Affiliation

¹ Institute for Chemical Reaction Science, Tohoku University, Sendai, 980-8578, Japan, and Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.

PMID: 10891135
DOI: 10.1021/jo000171m

Abstract

Polysubstituted anilines were prepared by the palladium-catalyzed cross-benzannulation of conjugated aminoenynes 1-4 with diynes 8. The reaction proceeded in a highly regioselective manner under mild conditions, and the anilines were obtained as single regioisomers. Our method complements the well-known precedures for the preparation of polysubstituted anilines which are widely used in organic synthesis.