Gene therapy for spine fusion

Orthop Clin North Am. 2000 Jul;31(3):473-84. doi: 10.1016/s0030-5898(05)70165-6.

Abstract

Gene therapy is a novel therapeutic modality for repair and regeneration of musculoskeletal tissues, including the spine. Various methods for therapeutic gene transfer are presented in this article. Several studies in which gene transfer has been used specifically to enhance spine fusion in animal models are reviewed.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins / genetics
  • Carrier Proteins / genetics
  • Cytoskeletal Proteins
  • Disease Models, Animal
  • Gene Transfer Techniques
  • Genetic Therapy / methods*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • LIM Domain Proteins
  • Spinal Fusion / methods*
  • Transforming Growth Factor beta*

Substances

  • Adaptor Proteins, Signal Transducing
  • BMP2 protein, human
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Proteins
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Intracellular Signaling Peptides and Proteins
  • LIM Domain Proteins
  • PDLIM7 protein, human
  • Transforming Growth Factor beta