Abstract
Natural azasugars have the ring oxygen substituted by nitrogen. They show potent inhibitory activity against glycosidases. The effect of substituting the ring carbon with nitrogen was examined with 1-azafagomine. 1-Azafagomine exhibited similar activity against processing glucosidase to that of fagomine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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1-Deoxynojirimycin / analogs & derivatives
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1-Deoxynojirimycin / pharmacology
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glucosidases / antagonists & inhibitors*
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Glucosidases / metabolism
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Glucosides / metabolism
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Humans
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Imino Pyranoses
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Indolizines / pharmacology*
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Piperidines / pharmacology
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Protein Processing, Post-Translational
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Substrate Specificity
Substances
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1-azafagomine
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Enzyme Inhibitors
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Glucosides
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Imino Pyranoses
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Indolizines
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Piperidines
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1-Deoxynojirimycin
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fagomine
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Glucosidases