Comparative genomics of the leprosy and tubercle bacilli

R Brosch; S V Gordon; K Eiglmeier; T Garnier; S T Cole

doi:10.1016/s0923-2508(00)00117-0

Comparative genomics of the leprosy and tubercle bacilli

Res Microbiol. 2000 Mar;151(2):135-42. doi: 10.1016/s0923-2508(00)00117-0.

Authors

R Brosch¹, S V Gordon, K Eiglmeier, T Garnier, S T Cole

Affiliation

¹ Unité de génétique moléculaire bactérienne, Institut Pasteur, Paris, France.

PMID: 10865959
DOI: 10.1016/s0923-2508(00)00117-0

Abstract

To achieve the quantum leap in understanding required to overcome two major human diseases, leprosy and tuberculosis, systematic and comparative genome analysis has been undertaken. New insight into the biology of their causative agents has been obtained and the principle findings are reported here.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Chromosome Mapping
Genome, Bacterial*
Genomics*
Humans
Mice
Mycobacterium leprae / genetics*
Mycobacterium leprae / pathogenicity
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / pathogenicity
Sequence Analysis, DNA