Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties

Arch Pharm (Weinheim). 2000 May;333(5):118-22. doi: 10.1002/(sici)1521-4184(20005)333:5<118::aid-ardp118>3.0.co;2-q.

Abstract

The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Adrenergic Agonists / chemical synthesis*
  • Adrenergic Agonists / pharmacology
  • Alzheimer Disease / drug therapy
  • Animals
  • Central Nervous System / drug effects
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Muscarinic Agonists / chemical synthesis*
  • Muscarinic Agonists / pharmacology
  • Protein Binding
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Rats
  • Receptor, Muscarinic M1
  • Receptors, Adrenergic / metabolism
  • Receptors, Muscarinic / metabolism
  • Synaptic Transmission / drug effects

Substances

  • Adrenergic Agonists
  • Enzyme Inhibitors
  • Muscarinic Agonists
  • Pyrazoles
  • Pyridines
  • Receptor, Muscarinic M1
  • Receptors, Adrenergic
  • Receptors, Muscarinic
  • Acetylcholinesterase