A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family

FEBS Lett. 2000 Jun 16;475(2):97-102. doi: 10.1016/s0014-5793(00)01640-9.

Abstract

We isolated a novel gene designated spinal cord-derived growth factor (SCDGF). Its expression was increased in chick spinal cords with embryonic development and decreased after hatching. The amino acid sequences of chick and human SCDGFs revealed a putative signal sequence followed by a CUB domain and a region homologous to the members of the platelet-derived growth factor/vascular endothelial growth factor family. Furthermore, human SCDGF secreted from the cells showed a mitogenic activity for 10T1/2 cells in vitro. These results led us to speculate that SCDGF plays an important role in the development of the spinal cord.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • CHO Cells
  • Cell Survival / drug effects
  • Chick Embryo
  • Cloning, Molecular
  • Cricetinae
  • DNA, Complementary / metabolism
  • Endothelial Growth Factors / genetics
  • Humans
  • Lymphokines / biosynthesis
  • Lymphokines / chemistry
  • Lymphokines / genetics*
  • Microscopy, Phase-Contrast
  • Molecular Sequence Data
  • Multigene Family
  • Platelet-Derived Growth Factor / biosynthesis
  • Platelet-Derived Growth Factor / chemistry
  • Platelet-Derived Growth Factor / genetics*
  • Protein Structure, Tertiary
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Spinal Cord / embryology
  • Spinal Cord / metabolism*
  • Time Factors
  • Transfection
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors

Substances

  • DNA, Complementary
  • Endothelial Growth Factors
  • Lymphokines
  • Platelet-Derived Growth Factor
  • RNA, Messenger
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors
  • platelet-derived growth factor C

Associated data

  • GENBANK/AB033829
  • GENBANK/AB033831