Abstract
Systemic and mucosal antibody responses against both the major subunit of colonization factor antigen I (CFA/I) of enterotoxigenic Escherichia coli (ETEC) and the somatic lipopolysaccharide expressed by recombinant bivalent Salmonella vaccine strains were significantly enhanced by coadministration of a detoxified derivative with preserved adjuvant effects of the ETEC heat-labile toxin, LT((R192G)). The results further support the adjuvant effects of LT((R192G)) and represent a simple alternative to improve responses against passenger antigens expressed by orally delivered Salmonella vaccine strains.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adjuvants, Immunologic / pharmacology*
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Animals
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Antibodies, Bacterial / biosynthesis*
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Antigens, Bacterial / administration & dosage
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Antigens, Bacterial / genetics
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Bacterial Proteins / administration & dosage
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Bacterial Proteins / genetics
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Bacterial Toxins / genetics
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Bacterial Toxins / pharmacology*
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / genetics
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Enterotoxins / genetics
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Enterotoxins / pharmacology*
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Escherichia coli / genetics
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Escherichia coli / immunology*
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Escherichia coli Proteins*
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Fimbriae Proteins*
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Immunity, Mucosal*
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Lipopolysaccharides / administration & dosage
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Mice
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Mice, Inbred BALB C
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Mutation
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Salmonella typhimurium / genetics
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Salmonella typhimurium / immunology
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / genetics
Substances
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Adjuvants, Immunologic
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Proteins
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Bacterial Toxins
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Bacterial Vaccines
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Enterotoxins
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Escherichia coli Proteins
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Lipopolysaccharides
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Vaccines, Synthetic
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colonization factor antigens
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Fimbriae Proteins
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heat-labile enterotoxin, E coli